The Range

NJ200 · Pen · Cellular energy research

NAD+ 2 mL multi-dose pen

Status varies — confirm locallyEvidence: Emerging

A coenzyme central to cellular energy metabolism. Widely studied in ageing biology; injectable and infusion presentations are not established approved therapies.

Information only

NAD+ is presented as reference information for registered healthcare professionals. Availability is subject to applicable law, prescription or Section 21 authorisation, and licensed pharmacy channels. No dosing, protocol or self-administration guidance is given, and nothing here is an offer of sale.

Mitochondrial energy metabolism — illustrative science visual.

Evidence highlights

What it is

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme present in all living cells and central to redox metabolism. Oral precursors are sold as supplements in many markets; injectable and IV presentations sit in a different regulatory category.

Mechanism being studied

NAD+ participates in redox reactions and serves as a substrate for sirtuins and PARP enzymes, pathways studied in ageing and metabolic research.

Human evidence

Human research largely concerns oral precursors and reports biomarker changes; clinical-outcome evidence remains emerging. Evidence for injectable or IV NAD+ delivering claimed benefits is limited.

Full research summary

Evidence & Regulation

Where the evidence for NAD+ sits, and the rules that apply to it

Every source below is a public, primary source — a literature index, a trials registry, or a regulator. They are reading directions for professionals, not endorsements, and they do not establish that any use of NAD+ is approved, safe or appropriate.

Citations

Further reading

  • Peer-reviewed NAD+ and NAD precursor literature indexed in PubMed.
  • National regulator guidance on supplements versus injectables.

How the regulation works

Registration comes before supply

In South Africa, a product intended to treat, prevent or otherwise affect the functioning of the body is a medicine and must be registered with SAHPRA before it may lawfully be sold. An unregistered compound cannot be advertised or supplied to the public, regardless of the evidence behind it.

SAHPRA — medicines registration

Section 21 is the professional access route

Where no registered alternative exists, a registered healthcare professional may apply to SAHPRA under Section 21 for authorisation to access an unregistered product for a named patient. That application is made by the clinician, not by the patient, and not by us.

Section 21 pathway

Prescription and dispensing stay with licensed channels

Any prescribing decision, dosing decision and dispensing step belongs to a registered healthcare professional and a licensed pharmacy. We publish reference information and analytical documentation only, and never dosing, protocols or self-administration guidance.

Prohibited in sport

Non-approved substances are prohibited at all times under the World Anti-Doping Code, including many research peptides. Athletes under testing jurisdiction should treat every compound on this site as prohibited unless their governing body confirms otherwise.

WADA Prohibited List

Status is jurisdiction-specific

A compound may be an approved medicine in one country, an investigational agent in a second, and an unregistered research chemical in a third. Always confirm the classification that applies where you practise before acting on any information here.

EMA medicines database

Information only — availability subject to applicable law, prescription/authorisation, and licensed healthcare/pharmacy channels. Nothing on this page is an offer to sell, and no dosing or self-administration guidance is provided.

South Africa — compliance notice

SAHPRA has publicly warned about unregistered peptide products being marketed to the South African public. In general, products intended to diagnose, treat, or otherwise alter bodily functions require registration or authorisation before they may lawfully be sold. ELLIVON BIOSCIENCES publishes reference information only and directs all clinical questions to registered healthcare professionals and licensed pharmacy channels.