Peptide Library

Cellular metabolism research

NAD+ 100 mg

Status varies — confirm locallyEvidence: Emerging

A coenzyme central to cellular energy metabolism. Widely studied in ageing biology; injectable and infusion presentations are not established approved therapies.

Mitochondrial energy metabolism — illustrative science visual.

What it is

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme present in all living cells and central to redox metabolism. Oral precursors are sold as supplements in many markets; injectable and IV presentations sit in a different regulatory category.

Mechanism being studied

NAD+ participates in redox reactions and serves as a substrate for sirtuins and PARP enzymes, pathways studied in ageing and metabolic research.

Human evidence

Human research largely concerns oral precursors and reports biomarker changes; clinical-outcome evidence remains emerging. Evidence for injectable or IV NAD+ delivering claimed benefits is limited.

Safety considerations

Infusion-related reactions are described anecdotally. Parenteral administration should only occur in an appropriate clinical setting. Safety information for this compound is incomplete outside of controlled settings. Reported considerations in the literature include injection-site reactions, unknown long-term effects, product-quality and sterility risks with unregistered preparations, and unpredictable interactions with existing medicines or conditions. Any consideration of use belongs with a registered healthcare professional who can assess the individual clinical picture.

Regulatory status

Regulatory classification differs between oral supplement forms and injectable presentations, and between countries. Confirm locally.

Certificate of analysis

Third-party analytical documentation for this compound is published for transparency and professional review. It confirms identity and purity of tested material only, and is not a marketing authorisation, a registration, or a recommendation for use.

View certificate (PDF)

Evidence & Regulation

Where the evidence for NAD+ sits, and the rules that apply to it

Every source below is a public, primary source — a literature index, a trials registry, or a regulator. They are reading directions for professionals, not endorsements, and they do not establish that any use of NAD+ is approved, safe or appropriate.

Citations

Further reading

  • Peer-reviewed NAD+ and NAD precursor literature indexed in PubMed.
  • National regulator guidance on supplements versus injectables.

How the regulation works

Registration comes before supply

In South Africa, a product intended to treat, prevent or otherwise affect the functioning of the body is a medicine and must be registered with SAHPRA before it may lawfully be sold. An unregistered compound cannot be advertised or supplied to the public, regardless of the evidence behind it.

SAHPRA — medicines registration

Section 21 is the professional access route

Where no registered alternative exists, a registered healthcare professional may apply to SAHPRA under Section 21 for authorisation to access an unregistered product for a named patient. That application is made by the clinician, not by the patient, and not by us.

Section 21 pathway

Prescription and dispensing stay with licensed channels

Any prescribing decision, dosing decision and dispensing step belongs to a registered healthcare professional and a licensed pharmacy. We publish reference information and analytical documentation only, and never dosing, protocols or self-administration guidance.

Prohibited in sport

Non-approved substances are prohibited at all times under the World Anti-Doping Code, including many research peptides. Athletes under testing jurisdiction should treat every compound on this site as prohibited unless their governing body confirms otherwise.

WADA Prohibited List

Status is jurisdiction-specific

A compound may be an approved medicine in one country, an investigational agent in a second, and an unregistered research chemical in a third. Always confirm the classification that applies where you practise before acting on any information here.

EMA medicines database

Information only — availability subject to applicable law, prescription/authorisation, and licensed healthcare/pharmacy channels. Nothing on this page is an offer to sell, and no dosing or self-administration guidance is provided.

South Africa — compliance notice

SAHPRA has publicly warned about unregistered peptide products being marketed to the South African public. In general, products intended to diagnose, treat, or otherwise alter bodily functions require registration or authorisation before they may lawfully be sold. ELLIVON BIOSCIENCES publishes reference information only and directs all clinical questions to registered healthcare professionals and licensed pharmacy channels.